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KMID : 0603820150210040218
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Journal of Experimental & Biomedical Science
2015 Volume.21 No. 4 p.218 ~ p.226
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Licochalcone B Exhibits Anti-inflammatory Effects via Modulation of NF-κB and AP-1
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Kim Jin-Kyung
Jun Jong-Gab
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Abstract
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The present study investigated the mechanisms of licochalcone B (LicB)-mediated inhibition of the inflammatory response in murine macrophages. RAW264.7 murine macrophages were cultured in the absence or presence of lipopolysacharide (LPS) with LicB. LicB suppressed the generation of nitric oxide and the pro-inflammatory cytokines interleukin (IL)-1β, IL-6 and tumor necrosis factor-α. LicB also inhibited the expression of mRNA for inducible nitric oxide synthase and pro-inflammatory cytokines induced by LPS. Moreover, LicB inhibited nuclear factor-κB (NF-κB) and activator protein-1 translocation into the nucleus in a dose-dependent manner. Thus, LicB mainly exerts its antiinflammatory effects by inhibiting the LPS-induced NF-κB and activator protein-1 signaling pathways in macrophages, which subsequently diminishes the expression and release of various inflammatory mediators. LicB shows promise as a therapeutic agent in inflammatory diseases.
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KEYWORD
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Inflammation, NF-κB, Macrophage, LPS, Licorice
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